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Showing 1–4 of 4 results

Advanced filters: Author: Keith Siklenka Clear advanced filters

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Two conditional transgenic mouse lines based on CRISPRa and CRISPRi enable epigenome editing in vivo.

Matthew P. Gemberling
Keith Siklenka
Charles A. Gersbach
Research02 Aug 2021
Nature Methods

Volume: 18, P: 965-974
Transcriptional and epigenetic regulators of human CD8⁺ T cell function identified through orthogonal CRISPR screens

CRISPR activation/interference screens identify transcriptional regulators of human CD8⁺ T cells, including BATF3. BATF3 overexpression counteracts T cell exhaustion and enhances cancer immunotherapy in in vivo models.

Sean R. McCutcheon
Adam M. Swartz
Charles A. Gersbach
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2211-2223
Multicenter integrated analysis of noncoding CRISPRi screens

This analysis provides 108 noncoding CRISPR screens collated by the ENCODE4 consortium and establishes experimental guidelines for future CRISPRi screens characterizing functional cis-regulatory elements.

David Yao
Josh Tycko
Steven K. Reilly
ResearchOpen Access19 Mar 2024
Nature Methods

Volume: 21, P: 723-734
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57