LC3 is required for canonical and non-canonical autophagy. Here, the authors uncover LAPTIN, a function of LC3 triggered by integrin LFA1 outside-in signaling, which activates AMPK to drive the co-clustering of LFA1 and LC3, thereby increasing LFA1 transport and lymphocyte adhesion.
- Naoyuki Kondo
- Yuko Mimori-Kiyosue
- Tatsuo Kinashi
