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Showing 1–5 of 5 results
Advanced filters: Author: Kelin Cheng Clear advanced filters

  • Khan et al. report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. The SETD2 amino terminus functions as a scaffold helping CDK1 associate with lamins during nuclear-envelope disassembly

    • Abid Khan
    • Cheng Zhang
    • Brian D. Strahl
    Research
    Nature Cell Biology
    Volume: 27, P: 1327-1341

  • Angelman syndrome is a neurodevelopmental disorder caused by the deletion of a single gene. Here, researchers discovered a small molecule that could be delivered peripherally to activate a dormant copy of the gene throughout the brain, providing a potential treatment opportunity.

    • Hanna Vihma
    • Kelin Li
    • Benjamin D. Philpot
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16