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Advanced filters: Author: Kelly A. Servage Clear advanced filters

A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism

Protein AMPylation regulates cellular processes. through the covalent addition of AMP to target proteins. Here, the authors develop a versatile enrichment strategy to profile AMPylated proteins and identify substrates of the mammalian AMPylase, Selenoprotein O.

Abner Gonzalez
Alex Pon
Anju Sreelatha
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-17
A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

Cryo-EM visualization of the bacterial pore-forming toxin VopQ bound to its host V-ATPase membrane-domain target reveals how cytotoxic effector proteins promote membrane disruption and inhibit ATPase function.

Wei Peng
Amanda K. Casey
Kim Orth
Research18 May 2020
Nature Structural & Molecular Biology

Volume: 27, P: 589-597
Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation

Kelly A. Servage
Karoliina Stefanius
Kim Orth
ResearchOpen Access07 May 2020
Scientific Reports

Volume: 10, P: 1-13