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Showing 1–4 of 4 results
Advanced filters: Author: Kelly McCastlain Clear advanced filters

  • Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.

    • Zhaohui Gu
    • Michelle Churchman
    • Charles G. Mullighan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Charles Mullighan, Jinghui Zhang and colleagues characterize a subtype of B-progenitor acute lymphoblastic leukemia with deregulated DUX4 and ERG. They find that aberrant DUX4 activation results in loss of ERG function, either through deletion or by the induction a novel transforming ERG isoform, ERGalt, that inhibits wild-type ERG activity.

    • Jinghui Zhang
    • Kelly McCastlain
    • Charles G Mullighan
    Research
    Nature Genetics
    Volume: 48, P: 1481-1489

  • Charles Mullighan, Stephen Hunger, Jinghui Zhang and colleagues report a genomic analysis of 264 pediatric and young adult T-lineage acute lymphoblastic leukemia (T-ALL) samples. They identify 106 candidate driver genes, 53 of which have not been described previously in pediatric T-ALL, as well as associations between mutations and disease stage or subtype.

    • Yu Liu
    • John Easton
    • Charles G Mullighan
    Research
    Nature Genetics
    Volume: 49, P: 1211-1218