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Showing 1–2 of 2 results
Advanced filters: Author: Ken Chih-Chien Cheng Clear advanced filters

  • An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8+ T cell activation.

    • Janna Heide
    • Agnes J. Bilecz
    • Ernst Lengyel
    Research
    Nature
    Volume: 645, P: 1051-1059

  • Merkel cell carcinoma (MCC) is a rare aggressive skin cancer with limited therapeutic options. In this work, the authors identify aurora kinase B (AURKB) as a critical therapeutic target for MCC, supported by tumour shrinkage and increased survival when using the AURKB inhibitor AZD2811 nanoparticle formulation in MCC preclinical models.

    • Tara Gelb
    • Khalid A. Garman
    • Isaac Brownell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15