Nature Search

Ancient DNA reveals the prehistory of the Uralic and Yeniseian peoples

Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

Tian Chen Zeng
Leonid A. Vyazov
David Reich
Research02 Jul 2025
Nature

Volume: 644, P: 122-132
Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia

Ancient DNA from Soqotra, an island off the coast of Yemen, evidences a population history differing from other areas of the Arabian Peninsula and suggests there has not been complete population replacement throughout the region between the Pleistocene and Holocene.

Kendra Sirak
Julian Jansen Van Rensburg
David Reich
Research08 Feb 2024
Nature Ecology & Evolution

Volume: 8, P: 817-829
Genomic insights into the formation of human populations in East Asia

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Chuan-Chao Wang
Hui-Yuan Yeh
David Reich
Research22 Feb 2021
Nature

Volume: 591, P: 413-419
A genetic history of the pre-contact Caribbean

Ancient DNA reveals genetic differences between stone-tool users and people associated with ceramic technology in the Caribbean and provides substantially lower estimates of population sizes in the region before European contact.

Daniel M. Fernandes
Kendra A. Sirak
David Reich
Research23 Dec 2020
Nature

Volume: 590, P: 103-110
DNA insights into Neolithic society

Ancient DNA can inform reconstructions of prehistoric social organization, but most evidence comes from elite burial grounds. Rivollat et al. analyse ancient DNA and archaeological evidence from 94 individuals at a non-monumental graveyard in France: Gurgy ‘les Noisats’. Their results reveal a patrilocal community who buried relatives close to one another.

Kendra Sirak
News & Views26 Jul 2023
Nature Human Behaviour

Volume: 7, P: 1245-1246
Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia

Little is known about the genetic landscape of people living in the Nile region prior to the Islamic migrations of the late 1st millennium CE. Here, the authors report genome-wide data for 66 ancient individuals to investigate the genetic ancestry of a Christian Period group from Kulubnarti.

Kendra A. Sirak
Daniel M. Fernandes
David Reich
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Author Correction: The genetic origin of the Indo-Europeans

Iosif Lazaridis
Nick Patterson
David Reich
Amendments and Corrections20 Feb 2025
Nature

Volume: 639, P: E14
The genetic origin of the Indo-Europeans

Ancient DNA reveals how the explosive expansion of Yamnaya steppe pastoralists began with a small community north of the Black Sea speaking ancestral Indo-European, and detects genetic links with Anatolian speakers, stemming from a common Indo-Anatolian homeland in the North Caucasus–lower Volga region.

Iosif Lazaridis
Nick Patterson
David Reich
Research05 Feb 2025
Nature

Volume: 639, P: 132-142
Entwined African and Asian genetic roots of medieval peoples of the Swahili coast

Analysis of ancient human DNA from the Swahili coast reveals that predominantly African female ancestors and Asian male ancestors formed families after around ad 1000 and lived in elite communities in coastal stone towns.

Esther S. Brielle
Jeffrey Fleisher
Chapurukha M. Kusimba
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 866-873
Ancient DNA and deep population structure in sub-Saharan African foragers

DNA analysis of 6 individuals from eastern and south-central Africa spanning the past approximately 18,000 years, and of 28 previously published ancient individuals, provides genetic evidence supporting hypotheses of increasing regionalization at the end of the Pleistocene.

Mark Lipson
Elizabeth A. Sawchuk
Mary E. Prendergast
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 290-296
The spread of steppe and Iranian-related ancestry in the islands of the western Mediterranean

The history of human populations in the islands of the central and western Mediterranean is poorly understood. Here, the authors generate ancient-DNA data from the Balearic Islands, Sicily and Sardinia, and estimate the level and timing of steppe pastoralist, Iranian and North African ancestries in these populations.

Daniel M. Fernandes
Alissa Mittnik
David Reich
Research24 Feb 2020
Nature Ecology & Evolution

Volume: 4, P: 334-345
Ethics of DNA research on human remains: five globally applicable guidelines

In this Perspective, a group representing a range of stakeholders makes the case for a set of five proposed globally applicable ethical guidelines for ancient human DNA research.

Songül Alpaslan-Roodenberg
David Anthony
Muhammad Zahir
Reviews20 Oct 2021
Nature

Volume: 599, P: 41-46
Author Correction: The spread of steppe and Iranian-related ancestry in the islands of the western Mediterranean

Daniel M. Fernandes
Alissa Mittnik
David Reich
Amendments and Corrections15 Apr 2020
Nature Ecology & Evolution

Volume: 4, P: 764
The genomic history of southeastern Europe

Genome-wide ancient DNA data from 225 individuals who lived in southeastern Europe between 12000 and 500 bc reveals that the region acted as a genetic crossroads before and after the arrival of farming.

Iain Mathieson
Songül Alpaslan-Roodenberg
David Reich
Research21 Feb 2018
Nature

Volume: 555, P: 197-203
Genomic insights into the origin of farming in the ancient Near East

Analysis of DNA from ancient individuals of the Near East documents the extreme substructure among the populations which transitioned to farming, a structure that was maintained throughout the transition from hunter–gatherer to farmer but that broke down over the next five thousand years.

Iosif Lazaridis
Dani Nadel
David Reich
Research25 Jul 2016
Nature

Volume: 536, P: 419-424
Genome-wide patterns of selection in 230 ancient Eurasians

The first genome-wide scan for selection using ancient DNA, based on data from 230 West Eurasians dating between to 6500 and 300 bc and including new data from 163 individuals among which are 26 Neolithic Anatolians, provides a direct view of selection on loci associated with diet, pigmentation and immunity.

Iain Mathieson
Iosif Lazaridis
David Reich
Research23 Nov 2015
Nature

Volume: 528, P: 499-503
Genomic insights into the peopling of the Southwest Pacific

Analysis of ancient DNA from four individuals who lived in Vanuatu and Tonga between 2,300 and 3,100 years ago suggests that the Papuan ancestry seen in present-day occupants of this region was introduced at a later date.

Pontus Skoglund
Cosimo Posth
David Reich
Research03 Oct 2016
Nature

Volume: 538, P: 510-513
Isolating the human cochlea to generate bone powder for ancient DNA analysis

The human cochlea is a rich source of endogenous DNA. This protocol describes how to use a sandblaster to isolate the cochlea from ancient skeletal remains and prepare bone powder for downstream DNA extraction.

Ron Pinhasi
Daniel M. Fernandes
Olivia Cheronet
Protocols06 Mar 2019
Nature Protocols

Volume: 14, P: 1194-1205
Stable carbon and nitrogen isotopes identify nuanced dietary changes from the Bronze and Iron Ages on the Great Hungarian Plain

Ashley McCall
Beatriz Gamarra
Ron Pinhasi
ResearchOpen Access10 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Integrating buccal and occlusal dental microwear with isotope analyses for a complete paleodietary reconstruction of Holocene populations from Hungary

Raquel Hernando
Beatriz Gamarra
Ron Pinhasi
ResearchOpen Access29 Mar 2021
Scientific Reports

Volume: 11, P: 1-21
The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness From Low Coverage Homozygous Genomes

Daniel Fernandes
Kendra Sirak
Jens Carlsson
ResearchOpen Access30 Jan 2017
Scientific Reports

Volume: 7, P: 1-10

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