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Showing 1–3 of 3 results
Advanced filters: Author: Kenneth C. Valkenburg Clear advanced filters

  • The genomic profiling of tumours has not been widely adopted in the clinic due to technical and practical hurdles. Here, the authors develop PGDx elio tissue complete, a scalable, standardised and FDA-cleared test comprising a targeted gene panel and automated machine-learning analysis, which detects clinically relevant sequence biomarkers in cancer samples.

    • Laurel A. Keefer
    • James R. White
    • Mark Sausen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • This Review discusses the challenges in accurately identifying rare prostate circulating tumour cells or bone marrow-derived disseminated tumour cells and the resulting need for prostate-specific, sensitive biomarkers for the detection of these cells in liquid biopsy samples.

    • Emma E. van der Toom
    • Haley D. Axelrod
    • Kenneth C. Valkenburg
    Reviews
    Nature Reviews Urology
    Volume: 16, P: 7-22

  • The tumour stroma is a component of the tumour microenvironment and has crucial roles in tumour initiation, progression, and metastasis. Most anticancer therapies target cancer cells specifically, but the tumour stroma can promote resistance to such therapies. Herein, the authors provide an overview of the complex cancer cell–tumour stroma interactions and discuss how novel treatment strategies should combine anticancer and antistromal agents.

    • Kenneth C. Valkenburg
    • Amber E. de Groot
    • Kenneth J. Pienta
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 15, P: 366-381