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Showing 1–10 of 10 results

Advanced filters: Author: Kenneth D Westover Clear advanced filters

Correction: Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E Pacold
Kyle R Brimacombe
David M Sabatini
Amendments and Corrections19 Jul 2016
Nature Chemical Biology

Volume: 12, P: 656
Discovery of a selective inhibitor of doublecortin like kinase 1

A highly selective inhibitor of the DCLK1/2 kinases is used to uncover the consequences of DCLK1 inhibition on viability, phosphosignaling and the transcriptome in patient-derived organoid models of pancreatic ductal adenocarcinoma.

Fleur M. Ferguson
Behnam Nabet
Nathanael S. Gray
Research06 Apr 2020
Nature Chemical Biology

Volume: 16, P: 635-643
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis

By screening for host factors that influence HIV-1 proviral fate, the authors identified ADAP1 as a tuner of KRAS–ERK–AP-1 axis, which consequentially influences gene programs relevant for T cell activation and latent virus reactivation.

Nora-Guadalupe P. Ramirez
Jeon Lee
Iván D’Orso
ResearchOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1-17
Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide

Sudershan R. Gondi
Asim K. Bera
Kenneth D. Westover
ResearchOpen Access03 Oct 2019
Scientific Reports

Volume: 9, P: 1-23
A structural model of a Ras–Raf signalosome

A structural model of a K-Ras nanocluster that promotes the stability and accessibility of active K-Ras and creates composite interfaces that facilitate Raf binding provides a framework to unravel MAPK signaling.

Venkatesh P. Mysore
Zhi-Wei Zhou
David E. Shaw
Research08 Oct 2021
Nature Structural & Molecular Biology

Volume: 28, P: 847-857
Data publication with the structural biology data grid supports live analysis

The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community.

Peter A. Meyer
Stephanie Socias
Piotr Sliz
ResearchOpen Access07 Mar 2016
Nature Communications

Volume: 7, P: 1-12
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A quantitative high-throughput screen identified an inhibitor of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine synthesis. This inhibitor limits one-carbon unit availability for nucleotide synthesis.

Michael E Pacold
Kyle R Brimacombe
David M Sabatini
Research25 Apr 2016
Nature Chemical Biology

Volume: 12, P: 452-458
Pharmacological targeting of the pseudokinase Her3

The use of ATP competitive kinase inhibitors against the pseudokinase Her3 has been largely unsuccessful. Hydrophobic tagging of a covalent kinase inhibitor promotes Her3 degradation and prevents productive dimerization and signaling.

Ting Xie
Sang Min Lim
Nathanael S Gray
Research19 Oct 2014
Nature Chemical Biology

Volume: 10, P: 1006-1012
Publisher Correction: Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide

Sudershan R. Gondi
Asim K. Bera
Kenneth D. Westover
Amendments and CorrectionsOpen Access30 Dec 2019
Scientific Reports

Volume: 9, P: 1
GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level

Qing Li
Xi Wei
Jin-Lu Shan
ResearchOpen Access09 May 2018
Cell Death & Disease

Volume: 9, P: 1-11