Song Yi Ko et al. show that cancer cell-derived small extracellular vesicles (sEVs) stimulate endothelial cell migration and tube formation through heparin-bound VEGF on the surface of sEVs. The authors find that interaction of VEGF with the sEV surface increases stability of VEGF and reduces its recognition by bevacizumab.
- Song Yi Ko
- WonJae Lee
- Honami Naora