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Showing 1–2 of 2 results
Advanced filters: Author: Kenny Mattonet Clear advanced filters

  • Xu and colleagues show that the transcription factor Hand2 promotes pdgfra expression during early cardiogenesis and that it can do so independently of direct DNA binding by interacting with Tcf3.

    • Yanli Xu
    • Rupal Gehlot
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 3, P: 1531-1548

  • Macrophages possess different G protein-coupled receptors such as the orphan receptor GPRC5B. Here the authors characterise the function of GPRC5B in macrophages in knockout mice showing that in the absence of GPRC5B there is increased inflammatory responses and macrophage activation because of reduced EP2-mediated anti-inflammatory effects.

    • Jeonghyeon Kwon
    • Haruya Kawase
    • Nina Wettschureck
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23