Nature Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Impact of uncomplicated controlled hypertension on thermoregulation during exercise-heat stress

Ashley P. Akerman
Sean R. Notley
Glen P. Kenny
Research14 Oct 2020
Journal of Human Hypertension

Volume: 35, P: 880-883
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling

Macrophages possess different G protein-coupled receptors such as the orphan receptor GPRC5B. Here the authors characterise the function of GPRC5B in macrophages in knockout mice showing that in the absence of GPRC5B there is increased inflammatory responses and macrophage activation because of reduced EP2-mediated anti-inflammatory effects.

Jeonghyeon Kwon
Haruya Kawase
Nina Wettschureck
ResearchOpen Access07 Feb 2025
Nature Communications

Volume: 16, P: 1-23
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription, thereby coupling glucose uptake to organismal energy expenditure.

Estifanos N. Habtemichael
Don T. Li
Jonathan S. Bogan
Research08 Mar 2021
Nature Metabolism

Volume: 3, P: 378-393
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and activates survival metabolic changes mediated by PFKFB3.

Chiara Montemurro
Hiroshi Nomoto
Slavica Tudzarova
ResearchOpen Access18 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Variability in the analysis of a single neuroimaging dataset by many teams

The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.

Rotem Botvinik-Nezer
Felix Holzmeister
Tom Schonberg
Research20 May 2020
Nature

Volume: 582, P: 84-88
Molecular, Cellular, and Structural Mechanisms of Cocaine Addiction: A Key Role for MicroRNAs

Sietse Jonkman
Paul J Kenny
Reviews12 Sept 2012
Neuropsychopharmacology

Volume: 38, P: 198-211
Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative

In January 2024, a Hevolution Alliance for Aging Biomarkers thinktank convened at Cold Spring Harbor to discuss the framework for creating an open and diverse data resource for developing reliable aging biomarkers. As the funding for this initiative has now been confirmed, we summarize recommendations and key milestones for its implementation.

Toshiko Tanaka
Felipe Sierra
Yousin Suh
News & Views06 Feb 2025
Nature Aging

Volume: 5, P: 188-192
Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs

Brennen McKenzie
Matthew Peloquin
Ellen R. Ratcliff
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial

A S Alberga
D Prud'homme
R J Sigal
Research23 Jul 2015
International Journal of Obesity

Volume: 39, P: 1494-1500

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