How important is ongoing neurogenesis to the function of the adult brain? Using genetic labeling and ablation methods in mice, Imayoshi and colleagues show that ongoing neurogenesis is required for maintenance of the olfactory bulb granule neuron population. In the hippocampus, blocking neurogenesis resulted in impaired contextual and spatial memory.
- Itaru Imayoshi
- Masayuki Sakamoto
- Ryoichiro Kageyama
