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Showing 1–3 of 3 results
Advanced filters: Author: Kenta Echigoya Clear advanced filters

  • Here the authors reveal that oncoprotein DEK binds the nucleosome, colocalizes with H3 K27 trimethylation and stimulates Polycomb repressive complex 2 methyltransferase through chromatin compaction, as revealed by the cryo-electron microscopy structures of nucleosome-bound DEK.

    • Tomoya Kujirai
    • Kenta Echigoya
    • Hitoshi Kurumizaka
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1183-1192

  • High-mobility group AT-hook (HMGA) proteins 1 and 2 are nonhistone chromatin proteins involved in different biological processes. Here the authors reveal that HMGA2 is a bona fide chromatin condensation factor that undergoes liquid–liquid phase separation, and that its chromatin condensation activity is important for the maintenance of mouse neural progenitor cells.

    • Naohiro Kuwayama
    • Tomoya Kujirai
    • Yukiko Gotoh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18