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Showing 1–3 of 3 results
Advanced filters: Author: Kerry Zobel Clear advanced filters

  • Proapoptotic signals trigger the transition of cIAP1 from an autoinhibited monomeric form to an activated dimer. NMR and time-resolved SAXS analyses reveal the conformational dynamics of the cIAP1 monomer that facilitates rapid and irreversible activation.

    • Aaron H Phillips
    • Allyn J Schoeffler
    • Wayne J Fairbrother
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 1068-1074

  • A high-throughput chemical screen followed by structure-guided chemical design leads to the first potent and selective small-molecule BCL-XL inhibitor.

    • Guillaume Lessene
    • Peter E Czabotar
    • Keith G Watson
    Research
    Nature Chemical Biology
    Volume: 9, P: 390-397