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Nature Communications (3)

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Showing 1–3 of 3 results

Advanced filters: Author: Kerstin Overkamp Clear advanced filters

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

This study characterizes the interaction between the clinical candidate anle138b and Aβ₄₀ fibrils in a lipid environment. The compound reduced fibril formation by approximately 75%, providing insights relevant to Alzheimer’s drug development.

Mookyoung Han
Benedikt Frieg
Christian Griesinger
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins

The authors show the RNA-induced droplet formation by a component of Cajal bodies and reveal the large nanoseconds mobility of glycine residues inside droplets as a molecular factor potentially contributing to the large dynamics of Cajal bodies.

Giuseppe Sicoli
Daniel Sieme
Nasrollah Rezaei-Ghaleh
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-12
A litmus test for classifying recognition mechanisms of transiently binding proteins

The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.

Kalyan S. Chakrabarti
Simon Olsson
Christian Griesinger
ResearchOpen Access01 Jul 2022
Nature Communications

Volume: 13, P: 1-11