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Showing 1–7 of 7 results
Advanced filters: Author: Kerstin Wolk Clear advanced filters

  • We classically consider the T cell compartment divided into cytotoxic CD8+ T cells and multiple, different helper CD4+ T cell subsets. Here the authors demonstrate that distinct memory CD8+ T cell subsets phenotypically inhabit CD4+ T cell like populations including some with helper-like characteristics.

    • Lucie Loyal
    • Sarah Warth
    • Andreas Thiel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

    • Catherine M Phelan
    • Karoline B Kuchenbaecker
    • Paul D P Pharoah
    Research
    Nature Genetics
    Volume: 49, P: 680-691

  • Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

    • Roger L Milne
    • Karoline B Kuchenbaecker
    • Jacques Simard
    Research
    Nature Genetics
    Volume: 49, P: 1767-1778

  • Interleukin 22 receptor 1 (IL-22R1) activity affects the development and course of disorders including psoriasis, ulcerative colitis, certain infections and tumours, without directly regulating immune cell function. Here, the authors describe the biology of IL-22 and highlight the therapeutic potential of modulating the activity of IL-22 and/or its receptor IL-22R1.

    • Robert Sabat
    • Wenjun Ouyang
    • Kerstin Wolk
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 21-38

  • Hidradenitis suppurativa is a debilitating chronic inflammatory disorder affecting the intertriginous skin characterized by localized skin lesions associated with numerous systemic comorbidities. The current health care of patients signals an enormous need for awareness and novel treatments. In this Primer, Sabat and colleagues review the epidemiology, pathophysiology, diagnosis and the various approaches for the management of this complex disease.

    • Robert Sabat
    • Gregor B. E. Jemec
    • Kerstin Wolk
    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1-20