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Showing 1–6 of 6 results
Advanced filters: Author: Kevan R. Thompson Clear advanced filters

  • There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells in mice.

    • Jinxiu Rui
    • Songyan Deng
    • Kevan C. Herold
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The EphB family of receptor tyrosine kinases can signal bidirectionally and functions in a kinase-dependent and kinase-independent manner. To determine the importance of the kinase activity of EphBs for axonal guidance and synaptogenesis, the authors used a chemical genetic method and generated knock-in mice that allow the kinase activity of EphBs to be inhibited without altering kinase-independent functions of EphBs. They find that specific inhibition of EphB kinase activity had no effect on synaptogenesis, but impaired axonal guidance, thereby implicating the kinase function of EphB in one neuronal process, but not other processes that are nevertheless dependent on EphBs.

    • Michael J Soskis
    • Hsin-Yi Henry Ho
    • Michael E Greenberg
    Research
    Nature Neuroscience
    Volume: 15, P: 1645-1654

  • RNA polymerase II is post-translationally modified on its C terminal domain and these modifications have been associated with different states of Pol II transcription. These modifications are now examined at a genome-wide level, and chemical inhibitors are used to argue that promoter-distal Ser7P is specifically placed anew by the Bur1 kinase.

    • Joshua R Tietjen
    • David W Zhang
    • Aseem Z Ansari
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1154-1161