Nature Search

Morphometry and mechanical instability at the onset of epithelial bladder cancer

Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

Franziska L. Lampart
Roman Vetter
Dagmar Iber
ResearchOpen Access07 Jan 2025
Nature Physics

Volume: 21, P: 279-288
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
Subcellular western blotting of single cells

Kevin A. Yamauchi
Amy E. Herr
ResearchOpen Access13 Feb 2017
Microsystems & Nanoengineering

Volume: 3, P: 1-9
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
SpatialData: an open and universal data framework for spatial omics

SpatialData is a user-friendly computational framework for exploring, analyzing, annotating, aligning and storing spatial omics data that can seamlessly handle large multimodal datasets.

Luca Marconato
Giovanni Palla
Oliver Stegle
ResearchOpen Access20 Mar 2024
Nature Methods

Volume: 22, P: 58-62
Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe²⁺-binding

Hou-Fu Guo
Chi-Lin Tsai
Jonathan M. Kurie
Amendments and CorrectionsOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1
Profiling protein expression in circulating tumour cells using microfluidic western blotting

Circulating tumour cells (CTCs) are rare cells found in the blood of certain cancer patients. Here, the authors develop a cytometry tool that appends a microfluidic western blot to a CTC isolation workflow and apply it to profile a panel of proteins in single CTCs isolated from ER+ breast cancer patients.

Elly Sinkala
Elodie Sollier-Christen
Amy E. Herr
ResearchOpen Access23 Mar 2017
Nature Communications

Volume: 8, P: 1-12
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis, provides molecular information about the hallmarks of ageing in a range of tissues and cell types.

Nicole Almanzar
Jane Antony
James Zou
Research15 Jul 2020
Nature

Volume: 583, P: 590-595
Molecular hallmarks of heterochronic parabiosis at single-cell resolution

A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

Róbert Pálovics
Andreas Keller
Tony Wyss-Coray
Research02 Mar 2022
Nature

Volume: 603, P: 309-314
ZIF-8 Derived, Nitrogen-Doped Porous Electrodes of Carbon Polyhedron Particles for High-Performance Electrosorption of Salt Ions

Nei-Ling Liu
Saikat Dutta
Kevin C.-W. Wu
ResearchOpen Access12 Jul 2016
Scientific Reports

Volume: 6, P: 1-7
Direct Production of Furfural in One-pot Fashion from Raw Biomass Using Brønsted Acidic Ionic Liquids

Babasaheb M. Matsagar
Shahriar A. Hossain
Kevin C.-W. Wu
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe²⁺-binding

Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.

Hou-Fu Guo
Chi-Lin Tsai
Jonathan M. Kurie
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-9
Ageing hallmarks exhibit organ-specific temporal signatures

Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

Nicholas Schaum
Benoit Lehallier
Tony Wyss-Coray
Research15 Jul 2020
Nature

Volume: 583, P: 596-602
A universal approach for the synthesis of mesoporous gold, palladium and platinum films for applications in electrocatalysis

Mesoporous metal films are used in many electrochemical applications. This protocol describes how to make mesoporous Au, Pt and Pd films using micelle templates and provides examples of how to use them (glucose detection and catalysis for alcohol oxidation).

Hyunsoo Lim
Kenya Kani
Yusuke Yamauchi
Protocols24 Aug 2020
Nature Protocols

Volume: 15, P: 2980-3008
Single cell–resolution western blotting

Single-cell-resolution western blotting concatenates an electrophoretic separation to downstream immunoprobing of unfixed mammalian cells to detect proteins, isoforms, and interactions that are not discernable by immunoreactivity alone.

Chi-Chih Kang
Kevin A Yamauchi
Amy E Herr
Protocols28 Jul 2016
Nature Protocols

Volume: 11, P: 1508-1530
Platinum-Free Counter Electrode Comprised of Metal-Organic-Framework (MOF)-Derived Cobalt Sulfide Nanoparticles for Efficient Dye-Sensitized Solar Cells (DSSCs)

Shao-Hui Hsu
Chun-Ting Li
Kevin C.-W. Wu
ResearchOpen Access10 Nov 2014
Scientific Reports

Volume: 4, P: 1-6
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.

Hou-Fu Guo
Neus Bota-Rabassedas
Jonathan M. Kurie
ResearchOpen Access19 Apr 2021
Communications Biology

Volume: 4, P: 1-10
Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation

Peter Haviernik
Carisa Lahoda
Kevin D Bunting
Research01 Nov 2004
Oncogene

Volume: 23, P: 9212-9219

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