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Showing 1–8 of 8 results
Advanced filters: Author: Kevin Boye Clear advanced filters

  • The interplay between neuronal activity and tumor progression is well-established. Here, the authors demonstrate that blockade of β-adrenergic signaling via administration of propranolol suppresses lung metastasis in multiple mouse tumor models by enhancing the accumulation of cytotoxic CD4 T cells while reducing CCR2+ monocytes, highlighting the re-purposing of β-blockers as a valid therapeutic approach for cancer treatment.

    • Klaire Yixin Fjæstad
    • Astrid Zedlitz Johansen
    • Daniel Hargbøl Madsen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.

    • Kevin Boyé
    • Luiz Henrique Geraldo
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.

    • Gael Genet
    • Kevin Boyé
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • In this immunological ancillary study of the PREVAC trial, the authors show that approved Ebola virus vaccines induce memory T-cell responses that persist during the five year follow-up after initial vaccination.

    • Aurélie Wiedemann
    • Edouard Lhomme
    • Huanying Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.

    • Torbjørn Elvsåshagen
    • Shahram Bahrami
    • Tobias Kaufmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.

    • Kevin Boyé
    • Nadège Pujol
    • Clotilde Billottet
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-20

  • Poulet et al investigate the role for the PRL-2 phosphatase in mouse retina, and find that loss of PRL-2 impairs vascular outgrowth and arteriovenous patterning. They find that PRL-2 s regulates endothelial cell migration and sprouting angiogenesis and acts through VEGF and NOTCH1 signalling.

    • Mathilde Poulet
    • Jacinthe Sirois
    • Andreas Bikfalvi
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14