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Showing 1–10 of 10 results
Advanced filters: Author: Kevin J. Selva Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody response in pre-pandemic cohorts and assess heterotypic reactivity to SARS-CoV-2.

    • Kevin J. Selva
    • Carolien E. van de Sandt
    • Amy W. Chung
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the course of ~5 months, showing that although neutralizing antibody responses drop off after ~4 months, B cell immune responses strengthen.

    • Adam K. Wheatley
    • Jennifer A. Juno
    • Stephen J. Kent
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a comparative assessment of the immune response between these compartments and their potential impact on immune-pathogenesis.

    • Wuji Zhang
    • Brendon Y. Chua
    • Katherine Kedzierska
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQO1.

    • Stephanie P. Totten
    • Young Kyuen Im
    • Josie Ursini-Siegel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Children with SARS-CoV-2 infection are more likely to have mild symptoms and may be asymptomatic, but underlying reasons remain unclear. Here, the authors show cellular, cytokine and antibody response to SARS-CoV-2 infection in three children who repeatedly tested negative for the virus by PCR, despite high exposure in the household.

    • Shidan Tosif
    • Melanie R. Neeland
    • Nigel W. Crawford
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Paul Hofman and colleagues show that a synonymous variant in IRGM, previously associated with risk of Crohn's disease, alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy. These findings implicate this synonymous polymorphism as a likely causal variant underlying the association of IRGM with Crohn's disease.

    • Patrick Brest
    • Pierre Lapaquette
    • Paul Hofman
    Research
    Nature Genetics
    Volume: 43, P: 242-245

  • Brian Brown et al. report the results of the Zurquí All Diptera Biodiversity Inventory project, one of the largest efforts to date to directly assess species richness of a megadiverse order of insects. The authors identified 41,001 flies to 4332 species, including 73 of the world's 160 Diptera families.

    • Brian V. Brown
    • Art Borkent
    • Manuel A. Zumbado
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-8