Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

Sydney Brenner
Maria Johnson
Kevin Corcoran
Research01 Jun 2000
Nature Biotechnology

Volume: 18, P: 630-634
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

Klim et al. illuminate pathomechanisms of ALS using pluripotent stem cells to identify transcripts altered in human motor neurons by perturbations to ALS protein TDP-43, finding the microtubule regulator STMN2 highly sensitive to TDP-43 malfunctions.

Joseph R. Klim
Luis A. Williams
Kevin Eggan
Research14 Jan 2019
Nature Neuroscience

Volume: 22, P: 167-179
Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories

Major depressive disorder is a heterogeneous condition with varied presentation of symptoms, comorbidities, and related genetic factors. This study aimed to identify clusters of major depressive disorder-related longitudinal multimorbidity trajectories and to characterize the clusters using genetic and risk factor data.

Andras Gezsi
Sandra Van der Auwera
Gabriella Juhasz
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-18
148 THREE FORMS OF CARNITINE PALMITOYL TRANSFERASE (CPT) II DEFICIENCY: (1) FATAL AT BIRTH OR (2) AT AGE 20 YEARS WITH CARDIAC FAILURE, OR (3) LIFE-COMPATIBLE WITH MODERATE MUSCLE SYMPTOMS

George Hug
Kevin Bove
Shirley Soukup
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 652
Evidence for an ice shelf covering the central Arctic Ocean during the penultimate glaciation

The development of pan-Arctic Ocean ice shelves during peak glacials was proposed in the 1970s, an idea that has been disputed due to lack of evidence. Here, the authors present geophysical mapping data supporting the presence of such an ice shelf during the peak of the penultimate glaciation ∼140–160 ka.

Martin Jakobsson
Johan Nilsson
Igor Semiletov
ResearchOpen Access18 Jan 2016
Nature Communications

Volume: 7, P: 1-10
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
A candidate antibody drug for prevention of malaria

Isolation and optimization of antibodies targeting the malaria parasite may offer the potential for immediate protection as a prophylactic intervention to prevent severe disease.

Katherine L. Williams
Steve Guerrero
Daniel E. Emerling
ResearchOpen Access02 Jan 2024
Nature Medicine

Volume: 30, P: 117-129
C₁₆-ceramide is a natural regulatory ligand of p53 in cellular stress response

Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C₁₆-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.

Baharan Fekry
Kristen A. Jeffries
Natalia I. Krupenko
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Global aquifers dominated by fossil groundwaters but wells vulnerable to modern contamination

Groundwater that predates the Holocene is commonly assumed to be unaffected by modern contamination. A global analysis of fossil groundwater suggests that modern contaminants are present in deep wells that tap fossil aquifers.

Scott Jasechko
Debra Perrone
James W. Kirchner
Research25 Apr 2017
Nature Geoscience

Volume: 10, P: 425-429
Location bias contributes to functionally selective responses of biased CXCR3 agonists

Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al. determine that agonist-biased CXCR3 signaling at endosomes differs from that at the plasma membrane, proposing location bias as an important phenomenon in signal transduction.

Dylan Scott Eiger
Noelia Boldizsar
Sudarshan Rajagopal
ResearchOpen Access04 Oct 2022
Nature Communications

Volume: 13, P: 1-17
webKnossos: efficient online 3D data annotation for connectomics

webKnossos is a browser-based tracing and annotation tool for 3D electron microscopy data sets that is optimized for seamless data viewing. The tool’s flight-mode view facilitates fast neurite tracing because of its egocentric viewpoint.

Kevin M Boergens
Manuel Berning
Moritz Helmstaedter
Research12 Jun 2017
Nature Methods

Volume: 14, P: 691-694
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Ryder Glacier in northwest Greenland is shielded from warm Atlantic water by a bathymetric sill

A bathymetric sill in Sherard Osborn Fjord, northwest Greenland shields Ryder Glacier from melting by warm Atlantic water found at the bottom of the fjord, according to high-resolution bathymetric mapping and oceanographic data.

Martin Jakobsson
Larry A. Mayer
June Padman
ResearchOpen Access04 Nov 2020
Communications Earth & Environment

Volume: 1, P: 1-10

Search

Filter By:

Search

Quick links