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Showing 1–3 of 3 results
Advanced filters: Author: Kevin M Woolfrey Clear advanced filters

  • This study shows that Epac2, a cAMP-activated Rap-GEF, acts downstream of D1/D5 dopamine receptor signaling to regulate dendritic spines and synaptic transmission. The authors also show that rare mutations of the EPAC2 gene that are associated with autism cause defects in Epac2-mediated spine remodeling.

    • Kevin M Woolfrey
    • Deepak P Srivastava
    • Peter Penzes
    Research
    Nature Neuroscience
    Volume: 12, P: 1275-1284

  • Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.

    • Mark L. Dell’Acqua
    • Kevin M. Woolfrey
    News & Views
    Nature Neuroscience
    Volume: 21, P: 1021-1022

  • Although symptoms and onsets of neuropsychiatric/neurodegenerative diseases may differ markedly, there is evidence that these diseases may share common cellular manifestation(s), particularly at the level of dendritic spines. Using autism spectrum disorder, schizophrenia and Alzheimer's disease as example neurological diseases that affect different stages of life, this review discusses recent evidence suggesting common defects in synaptic spines that may be underlie common pathogenesis.

    • Peter Penzes
    • Michael E Cahill
    • Kevin M Woolfrey
    Reviews
    Nature Neuroscience
    Volume: 14, P: 285-293