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Showing 1–3 of 3 results
Advanced filters: Author: Kevin M. Rattigan Clear advanced filters

  • The persistence of leukemic stem cells (LSCs) is known to limit the success of imatinib in patients with chronic myeloid leukaemia (CML). Here, the authors identify a reliance of these persisting LSCs on pyruvate carboxylase mediated pyruvate anaplerosis for survival after imatinib and demonstrate the therapeutic efficacy of targeting this using an inhibitor of mitochondrial pyruvate carrier.

    • Kevin M. Rattigan
    • Zuzana Brabcova
    • G. Vignir Helgason
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Metabolic rewiring is involved in acute myeloid leukaemia (AML) maintenance. Here the authors show that the inhibition of mannose-6-phosphate isomerase in the mannose metabolism pathway sensitizes AML to FLT3-tyrosine kinase inhibitor and standard chemotherapy via enhancing lipid peroxidation and ferroptotic cell death.

    • Keith Woodley
    • Laura S. Dillingh
    • Paolo Gallipoli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19