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Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

Nirsevimab binds the respiratory syncytial virus (RSV) fusion protein and has been tested for RSV prevention in clinical trials. Here, the authors analyse RSV from infections and show that binding site substitutions are rare and that over 99% of isolates remain susceptible to nirsevimab.

Bahar Ahani
Kevin M. Tuffy
Tonya Villafana
ResearchOpen Access19 Jul 2023
Nature Communications

Volume: 14, P: 1-10
A computational role for slow conductances: single-neuron models that measure duration

Scott L. Hooper
Einat Buchman
Kevin H. Hobbs
Research06 May 2002
Nature Neuroscience

Volume: 5, P: 552-556
Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment

During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not negatively affect effectiveness of the antibody therapy.

Robert W. Cross
Zachary A. Bornholdt
Thomas W. Geisbert
ResearchOpen Access27 Jul 2020
Nature Communications

Volume: 11, P: 1-8
Characterization of interactions of dietary cholesterol with the murine and human gut microbiome

Members of the murine and human gut microbiome can interact with dietary cholesterol. In particular, Bacteroides sulfotransferase activity can convert cholesterol to cholesterol sulfate and impact cholesterol levels in vivo.

Henry H. Le
Min-Ting Lee
Elizabeth L. Johnson
ResearchOpen Access18 Aug 2022
Nature Microbiology

Volume: 7, P: 1390-1403
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

Noam D. Beckmann
Phillip H. Comella
Alexander W. Charney
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Author Correction: Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

Bahar Ahani
Kevin M. Tuffy
Tonya Villafana
Amendments and CorrectionsOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-2
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Colton J. Bracken
Shion A. Lim
James A. Wells
Research20 Oct 2020
Nature Chemical Biology

Volume: 17, P: 113-121
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Masking interleukin-12 with a domain of the interleukin-12 receptor via a linker cleavable by tumour-associated proteases eliminates systemic immune-related adverse events and triggers potent therapeutic effects in mice bearing immunologically cold tumours.

Aslan Mansurov
Peyman Hosseinchi
Jeffrey A. Hubbell
Research09 May 2022
Nature Biomedical Engineering

Volume: 6, P: 819-829
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.

Ryan C. Thompson
Nicole W. Simons
Noam D. Beckmann
ResearchOpen Access08 Dec 2022
Nature Medicine

Volume: 29, P: 236-246
Establishment of an African green monkey model for COVID-19 and protection against re-infection

Geisbert and colleagues report that African green monkeys infected with the SARS-CoV-2 virus develop disease symptoms that closely resemble those seen in infected humans, making this animal model a useful surrogate to investigate immune responses to coronavirus infection.

Courtney Woolsey
Viktoriya Borisevich
Robert W. Cross
Research24 Nov 2020
Nature Immunology

Volume: 22, P: 86-98
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections05 Feb 2021
Nature Medicine

Volume: 27, P: 560
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections21 Aug 2020
Nature Medicine

Volume: 26, P: 1493
Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Correspondence27 Jul 2020
Nature Medicine

Volume: 26, P: 1157-1158
Regarding the rights and duties of Clinical Laboratory Geneticists in genetic healthcare systems: results of a survey in over 50 countries

Melody Caramins
Tony Baddrick
Kevin Carpenter
Correspondence10 Jul 2019
European Journal of Human Genetics

Volume: 27, P: 1761-1762

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