The role of the prostaglandin E1 receptor EP1 in hypertensive kidney disease remains controversial. EP1 mediates thick ascending limb chloride transport response to prostaglandin E2 and inhibits vasopressin-mediated water transport in the inner medullary collecting duct (IMCD). Though the IMCD transport is unaltered by hypertension, its responsiveness to vasopressin is reduced in diabetes. Moreover, EP1 is protective against glomerular and endothelial injury in hypertensive kidney disease, unlike its harmful role in diabetic kidney disease. This highlights the importance of carefully examining disease state (diabetes vs hypertension) when characterizing underlying disease processes.
- Rania Nasrallah
- Joseph Zimpelmann
- Richard L. Hébert
