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Showing 1–5 of 5 results
Advanced filters: Author: Kevin T. Ebata Clear advanced filters

  • The results of the phase 1/2 LIBRETTO-001 clinical trial has recently established the efficacy of the RET inhibitor selpercatinib in RET-driven cancers. Here, the authors characterize the molecular determinants of response and resistance in 72 LIBRETTO-001 lung and thyroid cancer patients treated at a single site.

    • Ezra Y. Rosen
    • Helen H. Won
    • Alexander Drilon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Vitamin C is a direct regulator of Tet enzyme activity and DNA methylation fidelity in mouse ES cells; addition of vitamin C promotes Tet activity, increases 5-hydroxymethlycytosine (5hmC) and DNA demethylation of many gene promoters, upregulates demethylated germline genes, and induces a state that more closely approximates that of the inner cell mass of the blastocyst.

    • Kathryn Blaschke
    • Kevin T. Ebata
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 500, P: 222-226

  • A subset of patients treated with selective TRK inhibitors (including the newly approved larotrectinib) develop off-target resistance mediated by genomic acquisition of MAPK pathway-activating alterations, and may benefit from combined targeted therapy.

    • Emiliano Cocco
    • Alison M. Schram
    • Maurizio Scaltriti
    Research
    Nature Medicine
    Volume: 25, P: 1422-1427

  • The effect of vitamin C deprivation on mouse germline development is analysed, revealing that maternal vitamin C is required for proper DNA demethylation and the development of fetal oocytes, whereas the lack of vitamin C during pregnancy leads to reduced female fecundity in the offspring.

    • Stephanie P. DiTroia
    • Michelle Percharde
    • Miguel Ramalho-Santos
    Research
    Nature
    Volume: 573, P: 271-275