The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA, which reveals how the APOBEC3H dimer binds around a short RNA duplex.
- Jennifer A. Bohn
- Keyur Thummar
- Janet L. Smith
