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Showing 1–6 of 6 results
Advanced filters: Author: Kfir Baruch Umansky Clear advanced filters

  • Sarig and Tzahor et al. show that the multiple sclerosis drug glatiramer acetate improves cardiac function and reduces scar area in rodent models of acute myocardial infarction and ischemic heart failure.

    • Gal Aviel
    • Jacob Elkahal
    • Rachel Sarig
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 1049-1066

  • Shakked et al. highlight the importance of cardiomyocytes’ redifferentiation after dedifferentiation and proliferation in cardiac repair and show that redifferentiation depends on negative feedback signaling and LATS1/2 Hippo pathway activity. Cardiomyocyte redifferentiation not only promotes the restoration of cardiac function but also protects against future insult.

    • Avraham Shakked
    • Zachary Petrover
    • Eldad Tzahor
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 383-398

  • Zhang et al. show that Egr1 regulates transient senescence during neonatal heart regeneration and upon agrin-mediated cardiac repair in adult mice, acting downstream of the integrin–FAK–ERK–Akt1 axis in cardiac fibroblasts.

    • Lingling Zhang
    • Jacob Elkahal
    • Eldad Tzahor
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 915-932

  • Pianca and Sacchi et al. unveil an important role for glucocorticoids and their receptor (GR) in cardiomyocyte cytoarchitectural/metabolic maturation, cell cycle exit and loss of regenerative ability, and they propose GR antagonization as a strategy for heart regeneration.

    • Nicola Pianca
    • Francesca Sacchi
    • Gabriele D’Uva
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 617-633

  • Aharonov et al. use in vivo genetic approaches to show that ErBB2-mediated YAP activation initiates epithelial–mesenchymal transition-like processes and dedifferentiation of cardiomyocytes to drive heart regeneration.

    • Alla Aharonov
    • Avraham Shakked
    • Eldad Tzahor
    Research
    Nature Cell Biology
    Volume: 22, P: 1346-1356

  • The extracellular matrix protein agrin promotes cardiac regeneration in adult mice after myocardial infarction; it modulates cardiac differentiation and proliferation by interacting with the dystrophin–glycoprotein complex, Yap and ERK-mediated signalling.

    • Elad Bassat
    • Yara Eid Mutlak
    • Eldad Tzahor
    Research
    Nature
    Volume: 547, P: 179-184