Nature Search

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

Human centromeric nucleosomes contain the specific CENP-A histone variant, which replaces canonical histone H3 and epigenetically marks the centromeres. Here the authors show that CENP-A nucleosomes form large supramolecular clusters during the G1 phase of the cell cycle which are arranged as rosette-like structures.

Leonid Andronov
Khalid Ouararhni
Ali Hamiche
ResearchOpen Access30 Sept 2019
Nature Communications

Volume: 10, P: 1-8
ANP32E is a histone chaperone that removes H2A.Z from chromatin

Human protein ANP32E is a histone chaperone that promotes removal of H2A.Z from chromatin.

Arnaud Obri
Khalid Ouararhni
Ali Hamiche
Research22 Jan 2014
Nature

Volume: 505, P: 648-653
Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

The crystal structure of human YL1, here established as an H2A.Z-deposition chaperone, in complex with an H2A.Z–H2B dimer reveals the molecular basis for the specificity of H2A.Z recognition.

Chrysa M Latrick
Martin Marek
Ali Hamiche
Research14 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 309-316
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

Prognostic markers for patients with COVID-19 are of critical importance in determining the course of SARS-CoV-2 infection and patient handling. Here the authors determine and apply a prognostic proteomic panel for risk and drug prediction in the management of SARS-CoV-2 infected patients.

Maryam A. Y. Al-Nesf
Houari B. Abdesselem
Fares Al-Ejeh
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-14
A multi-omics approach reveals dysregulated TNF-related signaling pathways in circulating NK and T cell subsets of young children with autism

Wared Nour-Eldine
Samia M. Ltaief
Abeer R. Al-Shammari
ResearchOpen Access30 Jul 2025
Genes & Immunity

Volume: 26, P: 462-474
Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks

Dania Awata
Vishnubalaji Radhakrishnan
Nehad M. Alajez
ResearchOpen Access09 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-13
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA

Trim24 and Trim33 are co-repressor complexes that suppress hepatocarcinogenesis. A new study now uncovers a function for Trim24 and Trim33 as repressors of VL30-type endogenous retroviruses in the liver. When derepressed, VL30 long terminal repeats (LTRs) function as promoter and enhancer elements deregulating expression of neighboring genes and generating noncoding enhancer RNAs that are required for LTR enhancer activity in hepatocytes.

Benjamin Herquel
Khalid Ouararhni
Irwin Davidson
Research03 Feb 2013
Nature Structural & Molecular Biology

Volume: 20, P: 339-346
Long noncoding RNA profiling unveils LINC00960 as unfavorable prognostic biomarker promoting triple negative breast cancer progression

Ramesh Elango
Vishnubalaji Radhakrishnan
Nehad M. Alajez
ResearchOpen Access23 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-12
Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks

Ramesh Elango
Sameera Rashid
Nehad M. Alajez
ResearchOpen Access12 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-14

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