Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Accurate whole human genome sequencing using reversible terminator chemistry

David R. Bentley
Shankar Balasubramanian
Anthony J. Smith
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 53-59
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
The DNA sequence and biological annotation of human chromosome 1

S. G. Gregory
K. F. Barlow
D. R. Bentley
Research18 May 2006
Nature

Volume: 441, P: 315-321
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.

Kathryn A. Ryan
Kevin R. Bewley
Miles W. Carroll
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
DNA sequence and analysis of human chromosome 9

S. J. Humphray
K. Oliver
I. Dunham
Research27 May 2004
Nature

Volume: 429, P: 369-374
The DNA sequence of human chromosome 22

I. Dunham
A. R. Hunt
K. P. O'Brien
Research02 Dec 1999
Nature

Volume: 402, P: 489-495
The DNA sequence and analysis of human chromosome 6

A. J. Mungall
S. A. Palmer
S. Beck
Research23 Oct 2003
Nature

Volume: 425, P: 805-811
The DNA sequence and analysis of human chromosome 13

A. Dunham
L. H. Matthews
M. T. Ross
Research01 Apr 2004
Nature

Volume: 428, P: 522-528
The DNA sequence and comparative analysis of human chromosome 10

P. Deloukas
M. E. Earthrowl
J. Rogers
Research27 May 2004
Nature

Volume: 429, P: 375-381
Advances in prostate cancer treatment

Several new drugs for advanced prostate cancer were approved in the past few years, and the pipelines are bristling with compounds that have diverse mechanisms of action. This article examines current and upcoming treatment modalities and provides a market outlook for prostate cancer.

Dominic Trewartha
Kimberley Carter
Comments & Opinion31 Oct 2013
Nature Reviews Drug Discovery

Volume: 12, P: 823-824
Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome

Kerstin Howe
Matthew D. Clark
Derek L. Stemple
Amendments and Corrections11 Dec 2013
Nature

Volume: 505, P: 248
Erratum: The DNA sequence and biological annotation of human chromosome 1

S. G. Gregory
K. F. Barlow
D. R. Bentley
Amendments and Corrections26 Oct 2006
Nature

Volume: 443, P: 1013
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
The DNA sequence and comparative analysis of human chromosome 20

P. Deloukas
L. H. Matthews
J. Rogers
Research20 Dec 2001
Nature

Volume: 414, P: 865-871
The zebrafish reference genome sequence and its relationship to the human genome

A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that approximately 70% of human protein-coding genes have at least one clear zebrafish orthologue.

Kerstin Howe
Matthew D. Clark
Derek L. Stemple
ResearchOpen Access17 Apr 2013
Nature

Volume: 496, P: 498-503
SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)

Sofía Sábato
Susana Benet
He Ping Yeo
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Intrinsic and extrinsic factors drive ontogeny of early-life at-sea behaviour in a marine top predator

Matt I. D. Carter
Deborah J. F. Russell
Kimberley A. Bennett
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-14
Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model

Tyler A. Lesh
Ana-Maria Iosif
Cameron S. Carter
Research15 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4185-4194
Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Heidi M. Harmon
Erik A. Jensen
Elaine Romano
Research04 Feb 2020
Journal of Perinatology

Volume: 40, P: 616-627
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation

Melissa D. Bauman
Tyler A. Lesh
Cameron S. Carter
ResearchOpen Access12 Apr 2019
Translational Psychiatry

Volume: 9, P: 1-8
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green
Jon E. Tyson
Kimberlee Weaver-Lewis
ResearchOpen Access04 Aug 2023
Journal of Perinatology

Volume: 43, P: 1398-1405
Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm

Jean Lowe
Janell F. Fuller
Mary Johnson
Research17 Jun 2022
Pediatric Research

Volume: 93, P: 689-695

Search

Filter By:

Search

Quick links