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Showing 1–3 of 3 results
Advanced filters: Author: Kimberly Klarmann Clear advanced filters

  • The innate immune sensor Toll-like receptor 4 controls inflammatory gene expression. Here the authors identify a network of positive and negative feedback loops involving the transcription factor C/EBPd and ubiquitin ligase substrate adaptor FBXW7a that regulate TLR4 levels and inflammatory signalling.

    • Kuppusamy Balamurugan
    • Shikha Sharan
    • Esta Sterneck
    Research
    Nature Communications
    Volume: 4, P: 1-12

  • The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.

    • Xia Ding
    • Arnab Ray Chaudhuri
    • Shyam K. Sharan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12