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Showing 1–2 of 2 results
Advanced filters: Author: Kimberly Z. Bullough Clear advanced filters

  • Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.

    • Maria C. Ferreira dos Santos
    • Cole P. Anderson
    • Elizabeth A. Leibold
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The iron chaperone poly(rC)-binding protein 1 (PCBP1) coordinates ferrous iron via its KH3 domain and, together with BolA2 and glutathione, forms a complex that is required for the assembly of [2Fe–2S] clusters on the cytosolic BolA2–Glrx3 chaperone.

    • Sarju J. Patel
    • Avery G. Frey
    • Caroline C. Philpott
    Research
    Nature Chemical Biology
    Volume: 15, P: 872-881