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Showing 1–8 of 8 results
Advanced filters: Author: Kimmo Rantalainen Clear advanced filters

  • Batista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize the requirements of 10E8 B cell precursors for entry and maturation in the germinal center.

    • Rashmi Ray
    • Torben Schiffner
    • Facundo D. Batista
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1083-1096

  • Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

    • Torben Schiffner
    • Ivy Phung
    • William R. Schief
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1073-1082

  • Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.

    • Kwinten Sliepen
    • Byung Woo Han
    • Rogier W. Sanders
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (pAb) responses elicited in rhesus macaques by HIV Env trimer immunogens and were able to determine up to 8 different polyclonal antibody structures in complex with their respective antigen from a single cryoEM dataset.

    • Aleksandar Antanasijevic
    • Leigh M. Sewall
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on the viral membrane.

    • Lei Zhang
    • Adriana Irimia
    • Michael B. Zwick
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.

    • Liwei Cao
    • Matthias Pauthner
    • James C. Paulson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14