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High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples

A platform for profiling single-cell density reveals insights into the regulation of cell density homeostasis and patient drug responses.

Weida Wu
Sarah H. Ishamuddin
Scott R. Manalis
Research20 May 2025
Nature Biomedical Engineering

Volume: 9, P: 1972-1981
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive malignancy with few effective treatment options available. Here, the authors use dynamic BH3 profiling to measure drug-induced mitochondrial priming and identify AZD8055 and navitoclax as a pro-apoptotic drug combination in ex vivo and preclinical MPM models.

Danielle S. Potter
Ruochen Du
Anthony Letai
ResearchOpen Access20 May 2023
Nature Communications

Volume: 14, P: 1-15
miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma

Relapsed disease after conventional cancer treatments is an obstacle in epidermal growth factor receptor (EGFR)-based targeted therapy. Here the authors show that tolerance to the EGFR inhibitor osimertinib in non-small-cell lung cancer is mediated by the effects of miR-147b on the tricarboxylic acid cycle and pseudohypoxia pathways, which can be manipulated with a miR-147b inhibitor.

Wen Cai Zhang
Julie M. Wells
Frank J. Slack
Research08 Apr 2019
Nature Metabolism

Volume: 1, P: 460-474
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

Li et al. define an adaptive resistance mechanism against FGFR inhibitor treatment in breast cancer attributed to loss of BRG1 chromatin recruitment, reactivation of YAP-dependent enhancers and upregulation of amino acid-induced mTORC1 activity.

Yihao Li
Xintao Qiu
Myles Brown
Research04 Nov 2021
Nature Cell Biology

Volume: 23, P: 1187-1198
Mechanisms and therapeutic implications of hypermutation in gliomas

Temozolomide therapy seems to lead to mismatch repair deficiency and hypermutation in gliomas, but not to an increase in response to immunotherapy.

Mehdi Touat
Yvonne Y. Li
Keith L. Ligon
Research15 Apr 2020
Nature

Volume: 580, P: 517-523
The nuclear envelope environment and its cancer connections

Aberrant nuclear morphology is already used as a diagnostic criterion for cancer, but why is the nucleus deformed in cancer cells? This Review discusses how components of the nuclear envelope and the adjoining lamina are deregulated in cancer cells and the consequences of this change in cell morphology.

Kin-Hoe Chow
Rachel E. Factor
Katharine S. Ullman
Reviews16 Feb 2012
Nature Reviews Cancer

Volume: 12, P: 196-209
Selective colonization ability of human fecal microbes in different mouse gut environments

Wei Zhou
Kin-hoe Chow
Julia Oh
Research15 Nov 2018
The ISME Journal

Volume: 13, P: 805-823
Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment

Peter M. Szabo
Amir Vajdi
Saurabh Saha
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-13
Correction: Selective colonization ability of human fecal microbes in different mouse gut environments

Wei Zhou
Kin-hoe Chow
Julia Oh
Amendments and Corrections14 Apr 2020
The ISME Journal

Volume: 14, P: 1912-1913

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