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Showing 1–3 of 3 results
Advanced filters: Author: Kinga Kamieniarz-Gdula Clear advanced filters

  • Proudfoot, Gullerova and colleagues show that mammalian Dicer localizes to the nucleus, where its levels are tightly regulated. Dicer interacts with RNA polymerase II and seems to restrict double-stranded (ds) RNA formation from convergent transcription. Dicer knockdown leads to accumulation of dsRNA, triggering the interferon response pathway and cellular apoptosis.

    • Eleanor White
    • Margarita Schlackow
    • Monika Gullerova
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 552-559

  • R-loops, which have been considered to be rare and potentially harmful transcriptional by-products, are now shown to be needed for antisense transcription and to induce repressive chromatin marks that reinforce pausing of transcription and thereby enhance its termination.

    • Konstantina Skourti-Stathaki
    • Kinga Kamieniarz-Gdula
    • Nicholas J. Proudfoot
    Research
    Nature
    Volume: 516, P: 436-439