FUS is an RNA/DNA-binding protein involved in gene expression regulation and associated with amyotrophic lateral sclerosis and frontotemporal dementia (FTLD) but the disease-causing mechanisms are unclear. Here the authors show that FUS regulates the stability of GluA1mRNA and dendritic maturation and plays a role in FTLD-associated behaviours.
- Tsuyoshi Udagawa
- Yusuke Fujioka
- Gen Sobue
