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Showing 1–4 of 4 results
Advanced filters: Author: Kipp Weiskopf Clear advanced filters

  • Michael Bishop and Harold Varmus proved that genetic changes could drive the formation of tumours. They were awarded the 1989 Nobel prize in Physiology or Medicine for discovering the origin of retroviral oncogenes. Bishop — now director of the GW Hooper Foundation at the University of California, San Francisco — tells Kipp Weiskopf about 40 years in cancer research.

    • Kipp Weiskopf
    Comments & Opinion
    Nature
    Volume: 514, P: S9-S10

  • Disrupting the CD47–SIRPα checkpoint in tumour macrophages and delivering a tumour-opsonizing monoclonal antibody maximizes the macrophages’ cooperative phagocytic potency.

    • Asaf Maoz
    • Kipp Weiskopf
    News & Views
    Nature Biomedical Engineering
    Volume: 7, P: 1057-1059

  • Centrioles are essential for the formation of centrosomes, cilia and flagella. The centriolar protein Polo-like-kinase 4 (Plk4) is a key regulator of centriole biogenesis and for maintaining constant centriole number in cells. These authors show that the centriolar protein Asterless (CEP152 in humans) interacts with Plk4 and Sas-4. They find that Asl functions as a scaffold for Plk4 and Sas-4 that facilitates self-assembly and duplication of the centriole, and organization of pericentriolar material.

    • Nikola S. Dzhindzhev
    • Quan D. Yu
    • David M. Glover
    Research
    Nature
    Volume: 467, P: 714-718