Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Kirill V. Tarasov Clear advanced filters

  • The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

    • Yordi J. van de Vegte
    • Ruben N. Eppinga
    • Pim van der Harst
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease.

    • William J. Young
    • Najim Lahrouchi
    • Patricia B. Munroe
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

    • Marcel den Hoed
    • Mark Eijgelsheim
    • Ruth J F Loos
    Research
    Nature Genetics
    Volume: 45, P: 621-631

  • Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells.

    • Georg B Ehret
    • Teresa Ferreira
    • Patricia B Munroe
    Research
    Nature Genetics
    Volume: 48, P: 1171-1184

  • On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

    • Ioanna Ntalla
    • Lu-Chen Weng
    • Patricia B. Munroe
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2 AMPK increases heart rate and prevents the adaptive bradycardia of endurance training in mice.

    • Arash Yavari
    • Mohamed Bellahcene
    • Houman Ashrafian
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • Arne Pfeufer and colleagues report a genome-wide association study of the electrocardiographic measurement of PR interval in seven population-based cohorts in the CHARGE consortium. They identify nine loci associated with PR interval and highlight candidate genes with a role in ion channels and cardiac development.

    • Arne Pfeufer
    • Charlotte van Noord
    • Susan R Heckbert
    Research
    Nature Genetics
    Volume: 42, P: 153-159

  • Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation.

    • Jessica van Setten
    • Jennifer A. Brody
    • Nona Sotoodehnia
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

    • Dan E Arking
    • Sara L Pulit
    • Christopher Newton-Cheh
    Research
    Nature Genetics
    Volume: 46, P: 826-836

  • Topological insulators with ordered moments of embedded magnetic atoms are viable platforms for quantum electronics, but the practical applications are restricted by the size of their crystals. The authors synthesize a Z2 topological insulator GexMn1-xBi2Te4 in the form of a large crystal with high structural perfection and tunable magnetic and electronic properties.

    • Alexander S. Frolov
    • Dmitry Yu. Usachov
    • Lada V. Yashina
    ResearchOpen Access
    Communications Physics
    Volume: 7, P: 1-11