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Showing 1–3 of 3 results
Advanced filters: Author: Kirk B. Burkhart Clear advanced filters

  • Double-stranded RNA interference (RNAi) in Caenorhabditis elegans is heritable; here a genetic screen for factors required for RNAi inheritance identifies the nuclear-localized Argonaute gene hrde-1, which acts in the germ cells of progeny to promote multigenerational inheritance of silencing and, also, germline immortality.

    • Bethany A. Buckley
    • Kirk B. Burkhart
    • Scott Kennedy
    Research
    Nature
    Volume: 489, P: 447-451

  • Small regulatory RNAs function both in the cytoplasm, inhibiting expression from messenger RNAs, and in the nucleus, silencing heterochromatin and preventing genome rearrangement. Now a new protein involved in RNA interference in the nucleus has been characterized. This protein, NRDE-2, associates with NRDE-3 and short interfering RNAs on nascent transcripts. This association prevents elongation of the transcripts by RNA polymerase II, making this a co-transcriptional form of gene silencing.

    • Shouhong Guang
    • Aaron F. Bochner
    • Scott Kennedy
    Research
    Nature
    Volume: 465, P: 1097-1101

  • Reduced insulin-like signaling is required for C. elegans response to many environmental stressors, but how distinct outcomes are achieved is unknown. The authors show that the cytosolic sulfotransferase SSU-1 controls neurohormonal signaling via NHR-1 to specify the animals’ osmotic stress response.

    • Nicholas O. Burton
    • Vivek K. Dwivedi
    • H. Robert Horvitz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9