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Advanced filters: Author: Kirk Robarge Clear advanced filters

  • The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysis to oxidative phosphorylation.

    • Aaron Boudreau
    • Hans E Purkey
    • Thomas O'Brien
    Research
    Nature Chemical Biology
    Volume: 12, P: 779-786