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Showing 1–5 of 5 results
Advanced filters: Author: Kirston Barton Clear advanced filters

  • Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and contains a high proportion of defective RNA.

    • Kirston Barton
    • Bonnie Hiener
    • Sarah Palmer
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • Familial cortical myoclonic tremor (FAME) has so far been mapped to regions on chromosome 2, 3, 5 and 8 and pentameric repeat expansions in SAMD12 were identified as cause of FAME1. Here, Corbett et al. identify ATTTT/ATTTC repeat expansions in intron 1 of STARD7 in individuals with FAME2.”

    • Mark A. Corbett
    • Thessa Kroes
    • Jozef Gecz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.

    • Ira W. Deveson
    • Bindu Swapna Madala
    • Tim R. Mercer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Single cell RNA sequencing generates short reads from one end of a template, providing incomplete transcript coverage and limiting identification of diverse sequences such as antigen receptors. Here the authors combine long read nanopore sequencing with short read profiling of barcoded libraries to generate full-length antigen receptor sequences.

    • Mandeep Singh
    • Ghamdan Al-Eryani
    • Alexander Swarbrick
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13