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Showing 1–12 of 12 results
Advanced filters: Author: Kirsty L. Spalding Clear advanced filters

  • Lipid turnover in tissues can be calculated from ratios of different carbon isotopes. Here the authors use this approach to study lipid turnover in two distinct adipose tissue depots and find that, in obese individuals, visceral fat is more lipolytic than subcutaneous fat.

    • Kirsty L. Spalding
    • Samuel Bernard
    • Peter Arner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

    • Netanel Loyfer
    • Judith Magenheim
    • Tommy Kaplan
    ResearchOpen Access
    Nature
    Volume: 613, P: 355-364

  • A legacy from above-ground testing provides a precise indicator of the year in which a person was born.

    • Kirsty L. Spalding
    • Bruce A. Buchholz
    • Jonas Frisén
    Research
    Nature
    Volume: 437, P: 333-334

  • This paper finds that the number of fat cells is set during childhood and adolescence, and adipocyte numbers for lean or obese individuals are subject to little variation during adulthood. Even after significant weight loss in adulthood and reduced adipocyte volume, adipocyte number remains the same.

    • Kirsty L. Spalding
    • Erik Arner
    • Peter Arner
    Research
    Nature
    Volume: 453, P: 783-787

  • The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.

    • Joshua Moss
    • Judith Magenheim
    • Yuval Dor
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • White adipose tissue serves a plethora of physiological functions, which are compromised in obesity. The mechanisms through which obese white adipose tissue contributes to pathologies including insulin resistance, dyslipidaemia, chronic inflammation, cancer and decreased fertility are emerging. In the future, these insights can be translated into novel drugs for obesity and obesity-associated diseases.

    • Carolina E. Hagberg
    • Kirsty L. Spalding
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 270-289

  • Radiocarbon dating is a common and reliable tool for measuring the age of a range of objects, from trees to historical artefacts and human remains. Hajdas et al. outline best practices for selecting and processing samples, as well as obtaining accurate measurements and age ranges. Ethical considerations for rare and culturally valuable materials are discussed.

    • Irka Hajdas
    • Philippa Ascough
    • Minoru Yoneda
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-26