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Advanced filters: Author: Kiruthika Ganesan Clear advanced filters

Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function

Arvie Rodriguez Abiero
Joanne M. Gladding
Laura A. Bradfield
ResearchOpen Access27 Sept 2025
Neuropsychopharmacology

P: 1-11
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.

Yao-Hsiang Shih
Ling-Hsien Tu
Yun-Ru Chen
ResearchOpen Access23 Nov 2020
Nature Communications

Volume: 11, P: 1-17

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Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

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