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Showing 1–3 of 3 results
Advanced filters: Author: Kivanç Birsoy Clear advanced filters

  • In this instalment of Career pathways, Kivanç Birsoy and Sarah Lessard recount their roads to scientific research and reflect on how each step in their training prepared them for life as a group leader.

    • Kivanç Birsoy
    • Sarah J. Lessard
    Reviews
    Nature Metabolism
    Volume: 3, P: 887-889

  • David Sabatini and colleagues report an insertional mutagenesis screen in haploid cells for resistance to the cancer drug candidate 3-bromopyruvate (3-BrPA). They find that SLC16A1, the gene that encodes MCT1, is frequently inactivated. MCT1 expression is required and sufficient for 3-BrPA uptake by cancer cells and may be used to predict cancers that are sensitive to 3-BrPA.

    • Kivanç Birsoy
    • Tim Wang
    • David M Sabatini
    Research
    Nature Genetics
    Volume: 45, P: 104-108