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Showing 1–2 of 2 results
Advanced filters: Author: Kiyoko Kamei Clear advanced filters

  • NF-κB signalling protein NEMO is the first physiological substrate for linear head-to-tail polyubiquitin chains. The heterodimeric ubiquitin ligase LUBAC catalyses the reaction and mice lacking a LUBAC subunit show defects in NF-κB signalling.

    • Fuminori Tokunaga
    • Shin-ichi Sakata
    • Kazuhiro Iwai
    Research
    Nature Cell Biology
    Volume: 11, P: 123-132

  • Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain.

    • Seshiru Nakazawa
    • Daisuke Oikawa
    • Fuminori Tokunaga
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14