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Showing 1–4 of 4 results

Advanced filters: Author: Klara Höning Clear advanced filters

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

The use of site-specific gene insertion is a powerful method for investigating gene function. Here the authors describe CRISPaint, a universal tagging system using CRISPR-Cas9 to insert genes in an NHEJ dependent manner.

Jonathan L. Schmid-Burgk
Klara Höning
Veit Hornung
ResearchOpen Access28 Jul 2016
Nature Communications

Volume: 7, P: 1-12
Warfarin and vitamin K compete for binding to Phe55 in human VKOR

The binding sites for the anticoagulant drug warfarin and for vitamin K on the human VKOR are determined through biochemistry and computational approaches. The results indicate a competitive mechanism of inhibition of VKOR by warfarin.

Katrin J Czogalla
Arijit Biswas
Johannes Oldenburg
Research12 Dec 2016
Nature Structural & Molecular Biology

Volume: 24, P: 77-85
A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

A library of DNA constructs enables high-throughput, ligation-free production of transcription activator–like effector (TALE) genes for genetic engineering.

Jonathan L Schmid-Burgk
Tobias Schmidt
Veit Hornung
Research16 Dec 2012
Nature Biotechnology

Volume: 31, P: 76-81
Frequently used bioinformatics tools overestimate the damaging effect of allelic variants

Line Lykke Andersen
Ewa Terczyńska-Dyla
Rune Hartmann
Research04 Dec 2017
Genes & Immunity

Volume: 20, P: 10-22