Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a common and severe adverse effect of cytostatic drugs that can limit dose and choice of chemotherapy, and can lead to delay or discontinuation of cytostatic treatment. Most drugs that are in use for neuropathic pain have failed to alleviate CIPNP in clinical trials. Here, Sisignano et al. review the mechanisms through which the most commonly used cytostatic drugs cause CIPNP, and suggest mechanism-based treatment options.
- Marco Sisignano
- Ralf Baron
- Gerd Geisslinger