The authors show that a developmental shift occurs in the dimensions of the calcium domain required for vesicle endocytosis at calyx of Held terminals. After hearing onset, endocytosis at mature synapses is largely driven by calcium nanodomains. Endocytosis becomes independent of calmodulin and calcineurin and completely dependent on GTP hydrolysis.
- Takayuki Yamashita
- Kohgaku Eguchi
- Tomoyuki Takahashi
