Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Nature

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Scientific Reports (21)
Nature Communications (7)
Nature (5)
Polymer Journal (4)
Hypertension Research (4)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (64)
Amendments and Corrections (1)
Reviews (1)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biological techniques
Biophysics
Cancer
Cell biology
Chemical biology
Chemistry
Computational biology and bioinformatics
Developmental biology
Diseases
Genetics
Health care
Immunology
Medical research
Microbiology
Neurology
Neuroscience
Physiology
Risk factors
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–50 of 66 results

Advanced filters: Author: Koichi Hattori Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Formation of Superstructure Composed of Modified Cyclodextrins as Molecular “Blocks” in Aqueous Solution with Host-Guest Complexation. Correlation of Chemical Structure of Modified Group with Complexation

Keiko Takahashi
Koichi Imotani
Masahiko Kitsuta
Research01 Mar 2001
Polymer Journal

Volume: 33, P: 242-247
Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study

Kazumoto Iijima
Mayumi Sako
Mari Oba
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Effects of renin–angiotensin system inhibitors in cancer patients: a systematic review and meta-analysis of randomized controlled trials

Satoshi Ishii
Yohei Hanajima
Yoichi Nozato
Research09 Oct 2025
Hypertension Research

P: 1-11
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Isotactic and Syndiotactic Pentacontamers (50mers) of Methyl Methacrylate Obtained by Fractionation with Preparative SFC: The GPC Analysis of the 50mers and Their Stereocomplex

Koichi Ute
Nobuo Miyatake
Koichi Hatada
Research01 Nov 1993
Polymer Journal

Volume: 25, P: 1153-1160
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

Yoshiki Tanaka
Christopher J. Hipolito
Osamu Nureki
Amendments and Corrections30 Jan 2020
Nature

Volume: 578, P: E19
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

Scott T Avecilla
Koichi Hattori
Shahin Rafii
Research21 Dec 2003
Nature Medicine

Volume: 10, P: 64-71
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1⁺ stem cells from bone-marrow microenvironment

Koichi Hattori
Beate Heissig
Shahin Rafii
Research01 Jul 2002
Nature Medicine

Volume: 8, P: 841-849
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).

Hirokazu Yagi
Maho Yagi-Utsumi
Koichi Kato
ResearchOpen Access13 Mar 2020
Nature Communications

Volume: 11, P: 1-9
Prevalence and management of hypertension in childhood, adolescent, and young adult cancer survivors: a systematic review and meta-analysis

Masanari Asai
Takumi Tokoro
Yoichi Nozato
Research08 Jul 2025
Hypertension Research

Volume: 48, P: 2453-2465
Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

Clonal dynamics and selection have not been fully understood in patient-derived xenografts (PDX) of acute myeloid leukemia (AML). Here, the authors generate 160 AML-PDX models to track the clonal dynamics of primary and relapsed AML, and find selectively enriched subclones that are associated with resistance to therapy.

Naomi Kawashima
Yuichi Ishikawa
Hitoshi Kiyoi
ResearchOpen Access25 Mar 2022
Nature Communications

Volume: 13, P: 1-11
The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas

Makoto Miyazaki
Ryo Otomo
Masato Enari
ResearchOpen Access10 May 2018
Cell Death Discovery

Volume: 4, P: 1-17
Identification of trypsin-degrading commensals in the large intestine

Colonization of trypsin-degrading commensal bacteria may contribute to the maintenance of intestinal homeostasis and protection against pathogen infection in humans and mice.

Youxian Li
Eiichiro Watanabe
Kenya Honda
ResearchOpen Access07 Sept 2022
Nature

Volume: 609, P: 582-589
Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke

Ryosuke Doijiri
Yuji Ueno
Takao Urabe
ResearchOpen Access29 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Development of ultra-deep targeted RNA sequencing for analyzing X-chromosome inactivation in female Dent disease

Shogo Minamikawa
Kandai Nozu
Kazumoto Iijima
Research19 Feb 2018
Journal of Human Genetics

Volume: 63, P: 589-595
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity

Eri Sakata
Yoshiki Yamaguchi
Koichi Kato
Research07 Jan 2007
Nature Structural & Molecular Biology

Volume: 14, P: 167-168
Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients

Norikazu Matsuo
Koichi Azuma
Tomoaki Hoshino
ResearchOpen Access04 Nov 2016
Scientific Reports

Volume: 6, P: 1-6
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

David Lyden
Koichi Hattori
Shahin Rafii
Research01 Nov 2001
Nature Medicine

Volume: 7, P: 1194-1201
ATP-dependent modulation of MgtE in Mg²⁺ homeostasis

MgtE is an Mg²⁺ transporter involved in Mg²⁺ homeostasis. Here, the authors report that ATP regulates the Mg⁺²-dependent gating of MgtE and use X-ray crystallography combined with functional studies to propose the molecular mechanisms involved in this process.

Atsuhiro Tomita
Mingfeng Zhang
Osamu Nureki
ResearchOpen Access27 Jul 2017
Nature Communications

Volume: 8, P: 1-11
Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency

Genetic variants of proteasome subunit genes have been shown to associate with perturbed immune function. Here authors show that a heterozygous missense variant of the immunoproteasome subunit β-type 9 causes an autoinflammatory/immune deficiency syndrome in humans and in a mouse model.

Nobuo Kanazawa
Hiroaki Hemmi
Tsuneyasu Kaisho
ResearchOpen Access24 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Preparation of Three-Armed Star Polystyrene by Reaction of Prepolymer Having a Terminal Functional Group with Triisocyanate

Toshiaki Kitano
Takashi Yamamoto
Koichi Ito
Research01 Sept 1987
Polymer Journal

Volume: 19, P: 1013-1023
Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

Iron export from vertebrate cells is mediated by ferroportin, which is suppressed by the peptide hormone hepcidin. Taniguchi et al. present crystal structures of a putative bacterial ferroportin homologue in both outward- and inward-facing states, providing insight into its transport mechanism.

Reiya Taniguchi
Hideaki E. Kato
Osamu Nureki
ResearchOpen Access13 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4⁺ hemangiocytes

David K Jin
Koji Shido
Shahin Rafii
Research30 Apr 2006
Nature Medicine

Volume: 12, P: 557-567
Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK

Nitrate/nitrite porters (NNP) play a central role in nitrate uptake in archaea, bacteria, fungi and plants. Here, Fukuda et al. use a liposome-based transport assay, X-ray crystallography and molecular dynamics simulation to reveal the dynamic nitrate/nitrite antiport mechanism of a bacterial NNP, NarK.

Masahiro Fukuda
Hironori Takeda
Osamu Nureki
ResearchOpen Access11 May 2015
Nature Communications

Volume: 6, P: 1-12
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

Shahin Rafii
David Lyden
Beate Heissig
Reviews01 Nov 2002
Nature Reviews Cancer

Volume: 2, P: 826-835
Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii

Yuji Nadatani
Toshio Watanabe
Yasuhiro Fujiwara
ResearchOpen Access25 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Takashi Yokota
Shintaro Kinugawa
Hiroyuki Tsutsui
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Characterization of amyloid β fibril formation under microgravity conditions

Maho Yagi-Utsumi
Saeko Yanaka
Koichi Kato
ResearchOpen Access12 Jun 2020
npj Microgravity

Volume: 6, P: 1-6
Discrete genetic subtypes and tumor microenvironment signatures correlate with peripheral T-cell lymphoma outcomes

Yasuhito Suehara
Kana Sakamoto
Mamiko Sakata-Yanagimoto
ResearchOpen Access31 Mar 2025
Leukemia

Volume: 39, P: 1184-1195
Two-step process for disassembly mechanism of proteasome α7 homo-tetradecamer by α6 revealed by high-speed atomic force microscopy

Toshiya Kozai
Taichiro Sekiguchi
Takayuki Uchihashi
ResearchOpen Access13 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Disassembly of the self-assembled, double-ring structure of proteasome α7 homo-tetradecamer by α6

Kentaro Ishii
Masanori Noda
Susumu Uchiyama
ResearchOpen Access14 Dec 2015
Scientific Reports

Volume: 5, P: 1-7
Involvement of surfactant protein D in emphysema revealed by genetic association study

Takeo Ishii
Koichi Hagiwara
Kozui Kida
Research21 Sept 2011
European Journal of Human Genetics

Volume: 20, P: 230-235
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling

Abe et al. profile, characterize and compare non-haematopoietic cells in normal human lymph nodes versus nodal lymphomas from patients, providing insights into stromal modelling in health and disease.

Yoshiaki Abe
Mamiko Sakata-Yanagimoto
Shigeru Chiba
ResearchOpen Access24 Mar 2022
Nature Cell Biology

Volume: 24, P: 565-578
Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

Several X-ray crystal structures of an H⁺-driven multidrug and toxic compound extrusion (MATE) transporter from Pyrococcus furiosus are presented, whose complex structure with macrocyclic peptides may help facilitate the discovery of efficient inhibitors of MATE transporters.

Yoshiki Tanaka
Christopher J. Hipolito
Osamu Nureki
Research27 Mar 2013
Nature

Volume: 496, P: 247-251
The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction

Akiomi Nagasaka
Chihiro Mogi
Hitoshi Kurose
ResearchOpen Access10 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

Hisashi Fukuyama
Hiroto Ishikawa
Shin Yamane
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers

Yousef Salama
Shinya Munakata
Beate Heissig
ResearchOpen Access17 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-13
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes

Yuto Kondo
Kohei Aoyama
Shinji Saitoh
ResearchOpen Access01 Jun 2020
Human Genome Variation

Volume: 7, P: 1-5
Structural basis for amino acid export by DMT superfamily transporter YddG

The X-ray structure of the drug/metabolite transporter (DMT) protein YddG from Starkeya novella reveals a new membrane transport topology, with ten transmembrane segments in an outward-facing state and two pseudo-symmetric inverted structural repeats.

Hirotoshi Tsuchiya
Shintaro Doki
Osamu Nureki
Research30 May 2016
Nature

Volume: 534, P: 417-420
Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

Takashi Yokota
Shintaro Kinugawa
Hiroyuki Tsutsui
Research14 Jul 2011
Hypertension Research

Volume: 34, P: 1029-1034
Statistical determination of chemical composition and monomer sequence distribution of poly(methyl methacrylate-co-tert-butyl methacrylate)s by multivariate analysis of ¹³C NMR spectra

Multivariate analysis was applied to the ¹³C nuclear magnetic resonance spectra of homopolymers, homopolymer blends and copolymers of methyl methacrylate (MMA) and tert-butyl methacrylate (TBMA). The first (PC1) and second (PC2) principal components reflected chemical composition of the copolymers and fraction of the MMA-TBMA dyad sequence (f_MT), respectively. Dyad and triad sequence distributions of copolymers that were obtained at higher conversions were successfully determined by partial least squares regression with those of copolymers obtained at low conversions as a training set.

Hikaru Momose
Tomoya Maeda
Koichi Ute
Research20 Jun 2012
Polymer Journal

Volume: 44, P: 808-814
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution

Sakurako Suma
Yasuhito Suehara
Mamiko Sakata-Yanagimoto
ResearchOpen Access27 Nov 2023
Leukemia

Volume: 38, P: 340-350
The transcriptional landscape of αβ T cell differentiation

The differentiation of αβ T cells is a complex process. Using data sets from the Immunological Genome Project, Benoist and colleagues identify candidate mediators of key transitions during thymocyte selection and maturation.

Michael Mingueneau
Taras Kreslavsky
Shannon Turley
Research05 May 2013
Nature Immunology

Volume: 14, P: 619-632

Previous page
page 1
page 2
Next page

Search

Search articles by subject, keyword or author

Show results from

Advanced search

Quick links

Explore articles by subject
Find a job
Guide to authors
Editorial policies

Nature.com

nature.com sitemap

About Nature Portfolio

About us
Press releases
Press office
Contact us

Discover content

Journals A-Z
Articles by subject
protocols.io
Nature Index

Publishing policies

Nature portfolio policies
Open access

Author & Researcher services

Reprints & permissions
Research data
Language editing
Scientific editing
Nature Masterclasses
Research Solutions

Libraries & institutions

Librarian service & tools
Librarian portal
Open research
Recommend to library

Advertising & partnerships

Advertising
Partnerships & Services
Media kits
Branded content

Professional development

Nature Awards
Nature Careers
Nature Conferences

Regional websites

Nature Africa
Nature China
Nature India
Nature Japan
Nature Middle East

Privacy Policy
Use of cookies
Legal notice
Accessibility statement
Terms & Conditions
Your US state privacy rights

© 2025 Springer Nature Limited